Central Nervous System Lipoproteins
نویسنده
چکیده
Lipoprotein and cholesterol metabolism in the brain involves metabolic pathways that are regulated independently of those in the peripheral circulation and tissues. The blood–brain barrier (BBB) restricts plasma lipids, including cholesterol and plasma lipoproteins, from entering or leaving the central nervous system (CNS). In the CNS, cholesterol is synthesized by astrocytes, oligodendrocytes, microglia, and to a lesser extent neurons. CNS cholesterol homeostasis is maintained by 24S-hydroxycholesterol produced by neurons. CNS lipoproteins redistribute cholesterol and lipids to neurons and other brain cells to maintain neuronal plasticity, which requires repair and remodeling of membranes, organelle biogenesis, and synaptogenesis. ApoE is critical in this process through the formation of apoE-enriched CNS lipoproteins that are high-density lipoprotein (HDL) like but are unlike the major apoAI-enriched HDL in plasma.
منابع مشابه
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